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ProtoFacts

As a practitioner, how can you help your patients who want to focus on maintaining cardiovascular health?

Once you have a good idea of a patient’s cardiovascular health needs, it is time to discuss a tailored plan that ts their unique situation and lifestyle. Protocol For Life Balance® offers a wide range of cardiovascular support products to help you design a customized plan that  perfectly fits the needs of your patient.*

Read the ProtoFact

What is the link between glycogen synthase kinase-3 and resveratrol, curcumin & berberine?

These three well known nutraceuticals have been extensively researched in the past few decades and are individually known for their powerful free radical scavenging properties.*

However, it is now well established that it is not their only function in the body. Each compound possesses multiple functions that contribute to their health promoting properties.*

We will focus here on one function: their ability to interact with the GSK-3 signaling pathway.*

First, what is the GSK-3?

Glycogen synthase kinase-3 (GSK-3) is an enzyme belonging to the family of serine/threonine kinases that is an important ubiquitous regulator of many cellular structures and functions. GSK-3 is present in the cytosol and nucleus of cells, as well as in mitochondria; its functions vary depending on its intracellular localization. More than 100 substrates have been identified for GSK-3, including metabolic and signaling proteins such as acetyl-CoA carboxylase, glycogen synthase, pyruvate dehydrogenase, structural proteins, and many transcription factors. For cells to function properly, GSK-3 needs to be tightly regulated. GSK-3 is active under basal cellular functional conditions and requires extracellular signaling for its inactivation. There is a complex system of cellular pathways regulating GSK-3’s inactivation, and insulin, growth factors, and certain amino acids can trigger its inactivation.

Among GSK-3’s many functions, regulation of glycogen synthesis, cellular glucose uptake, and expression of genes regulated by insulin seem especially relevant for the healthy regulation of glucose metabolism. GSK-3 therefore, appears to oppose the action of insulin at the cellular level.*

There is a growing interest in researching molecules that can specifically inactivate GSK-3 and would therefore be good candidates for the support of healthy glucose metabolism, cardiovascular health, and healthy brain function.*

How do resveratrol, curcumin & berberine interact with GSK-3?

Laboratory experiments suggest that resveratrol, curcumin, and berberine may help to regulate GSK-3 activity either by directly inhibiting GSK-3 enzymatic activity or by interfering at different levels of the complex pathways GSK-3 is involved in within cells. While there is not yet any human clinical data confirming how the interaction between these three nutraceuticals and GSK-3 functions results in improved health status, preclinical data are very encouraging.

At Protocol For Life Balance® we offer resveratrol, berberine, and curcumin (four products) in several supplements. You can recommend taking them individually or in combination for complementary effects. Taking them in combination makes perfect sense, notably when thinking of their common putative action on GSK-3 and its regulation pathways.*

Weight Management*

In January, holiday weight gain and weight management are common topics in the media. Many people start the new year with resolutions of maintaining or improving their health, notably by paying more attention to their weight.

As a practitioner, how can you help your patients on the arduous journey to their ideal weight, and how can you help them navigate the ocean of information related to weight management that they read through social media, magazines, news outlets, and the internet?

Is holiday weight gain a real problem?
According to epidemiological observational studies done in the U.S., the average weight gain is small but significant – around 1 lb. over the November to January period. That weight gain is largely fat gain and affects more people at the higher end of the BMI scale. It appears that this average weight gain is retained and is a major contributor to the average annual weight gain observed in adults in the United States.

What should you recommend to your patients in terms of weight management?
Today’s consensus is that there is no magic bullet when it comes to weight management and there is no one-size-ts-all solution. An individualized intervention that takes into consideration the patient’s physiological and psychological needs is ideal. After assessing the patient’s health history, his/her expectations, and his/her physical and biological status, including endocrine health, you can prepare an action plan with him/her including lifestyle changes and adequate supplementation.

How can Protocol For Life Balance® help you recommend the right supplements for the right weight management plan?
We propose 6 categories of products that can help you recommend the right combination of supplements to help your patients in their effort to reach a healthy weight.*

weight management diagram

 

Positive mood and relaxation support*

GABA (Gamma-Aminobutyric Acid)
• Natural neurotransmitter*
• Main inhibitory neurotransmitter in the brain*
• Healthy brain levels associated with a relaxed mood*
750 mg per serving; 1 to 2 servings/day

Other Neurotransmitter Precursors/Cofactors*

SAMe (S-adenosylmethionine)
• Maintenance of a positive mood*
• Critical cofactor for the chemical activation
(transmethylation) of neurotransmitters such as
dopamine and serotonin*
200 mg per serving; 2 to 4 servings/day
• Also available as 400 mg per serving; 2 to 3 servings/day
– available in enteric-coated oval tablets

Mucuna
• Standardized to 15% L-Dopa, the precursor of dopamine*
• Promotes a positive mood*
800 mg per serving; 1 serving/day

Myo-inositol
• Inositols are cyclic carbohydrates present in all cells; among them, myo-inositol is the most abundant inositol
isomer present in the central nervous system
• Supports healthy mood and emotional wellness*
• Supports restful sleep*
6 g per serving; 2 servings/day

Melatonin
• Supports healthy sleep cycle*
• Modulates neuronal activity*
3 mg per serving; 1 serving/day as a peppermint-flavored lozenge with vitamin B6
• Also available as a stand-alone 10 mg veg capsule

Ashwagandha
• Helps the body to adapt to temporary emotional stress*
• GABA-like activity in laboratory experiments*
450 mg per serving; 2 to 3 servings/day

Protosorb™ Magnesium
• Delivers magnesium to the nervous system*
• Magnesium regulates neuronal synapse density, and Mg availability in the brain is necessary for the stability and adaptability of these neuronal connections*
• Promotes a relaxed mood in laboratory
experiments*
2,000 mg per serving (144 mg magnesium); 1 capsule in mid-afternoon and 2 capsules one hour before sleep

Phosphatidyl Serine
• Supports neuronal membrane uidity and facilitates intercellular communication*
• Supports the normal utilization of neurotransmitters in the brain including those involved in mood regulation*
• Supports mental acuity*
300 mg per serving as stand-alone; 1 serving/day
• Also available in 100 mg per serving with ginkgo; 1 serving 1 to 3 times/day

Serotonin, Melatonin Precursors*

L-Tryptophan
• Essential Amino Acid
• Encourages positive mood*
• Supports relaxation*
• Supports restful sleep*
1,000 mg per serving; 2 servings/day
(P0166, P0167, P0169)

5-HTP (5-hydroxytryptophan)
• Plant-based 5-HTP from Griffonia simplicifolia
• Supports a positive mood*
100 mg per serving; 1 to 3 servings/day

5-HTP Blend
• With niacin & B-6
• Completed with glycine, taurine & inositol
• Supports a positive mood*
• Plant-based 5-HTP from Griffonia simplicifolia
200 mg 5-HTP per serving; 1 to 2 servings/day

Myo-inositol
• Inositols are cyclic carbohydrates present in all cells; among them, myo-inositol is the most abundant inositol isomer present in the central nervous system
• Supports healthy mood and emotional wellness*
• Supports restful sleep*
6 g per serving; 2 servings/day

Melatonin
• Supports healthy sleep cycle*
• Modulates neuronal activity*
3 mg per serving; 1 serving/day as a peppermint- flavored lozenge with vitamin B6
• Also available as a stand-alone 10 mg veg capsule

Ashwagandha
• Helps the body to adapt to temporary emotional stress*
• GABA-like activity in laboratory experiments*
450 mg per serving; 2 to 3 servings/day

Protosorb™ Magnesium
• Delivers magnesium to the nervous system*
• Magnesium regulates neuronal synapse density, and Mg availability in the brain is necessary for the stability and adaptability of these neuronal connections*
• Promotes a relaxed mood in laboratory experiments*
2,000 mg per serving (144 mg magnesium); 1 capsule in mid-afternoon and 2 capsules one hour before sleep

Phosphatidyl Serine
• Supports neuronal membrane fluidity and facilitates intercellular communication*
• Supports the normal utilization of neurotransmitters in the brain including those involved in mood regulation*
• Supports mental acuity*
300 mg per serving as stand-alone; 1 serving/day
• Also available in 100 mg per serving with ginkgo; 1 serving 1 to 3 times/day

• With Relora®, a plant-based blend of Magnolia officinalis bark and Phellodendron amurense bark
• Supports a healthy adrenal response*
• Temporarily relieves typical daily stress*
• 200 mg Relora® per serving; 3 servings/day
Herbal Menopause
• Plant-based supplement from Phlomis umbrosa, Cynanchum wilfordii, and Angelica gigas Nakai
• Alleviates menopause manifestations such as nervousness, occasional sleeplessness, and difficulty in maintaining a positive mood*
257 mg per serving; 2 servings/day

New products in 2018

We launched 14 new products in 2018. To see them all … Read the Protofact

What makes Activated Charcoal a great supplement*

Activated Charcoal is a supplement specifically designed to offer high adsorbancy thanks to its incredible physical properties.* To learn more about it … Read the ProtoFact

Clinical Strength Prostate-B™

Structural changes in prostatic tissue occur over time as a result of normal aging. These changes may be associated with difficulty in urinating, and other issues*… Read the Insight

 

Achieve Healthy Body Composition*

In conjunction with a sensible diet and regular exercise, dietary supplements can be a great way for your patients to better manage their weight and maintain healthy body composition.* Protocol for Life Balance offers several targeted formulations… Read the Insight

Best Products for Fall

We asked Dr. Ber, Assistant Director of Science and Nutrition at Protocol For Life Balance®, which supplements are best to prepare for winter… Read the Protofact

Achieve Healthy Intestinal Flora*

Prebiotic Powder XOS  features PreticX™, a prebiotic complex comprised of xylooligosaccharides (XOS). XOS are selective, bifidogenic prebiotics shown to increase the amount of healthful Bifidobacteria in the GI tract of healthy individuals, which is particularly beneficial with aging*… Read the ProtoFact

Achieve Healthy Microvascular Function*

1,000 mg Arginine is a conditionally essential basic amino acid involved primarily in urea metabolism and excretion, as well as in DNA synthesis and protein production.* It is an important precursor of nitric oxide (NO) and thus plays a role in the dilation of blood vessels.* To learn more about it … Read the ProtoFact

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.